Resolving the bias-precision paradox with stochastic causal representation learning for personalized medicine

Estimating individualized treatment effects from longitudinal observational data is central to data-driven medicine, yet existing methods face a fundamental limitation: reducing confounding bias often suppresses clinically informative heterogeneity, degrading patient-specific predictions. Here, we identify this tension as a bias-precision paradox in causal representation learning and introduce sampling-based maximum mean discrepancy (sMMD), a stochastic alignment strategy that replaces global adversarial balancing with subset-level matching. We instantiate this approach in a framework for counterfactual outcome prediction with attribution-grounded interpretability. Across two large-scale ICU cohorts (n = 27,783), our framework improves accuracy under distribution shift, reducing error by up to 11.5% and substantially increasing recall in high-risk tasks. Mechanistic analyses show that sMMD selectively preserves clinically decisive variables. In human-AI evaluation, our method outperforms clinicians-in-training and large language models, and improves clinician accuracy by 14.7% while reducing decision time, enabling interpretable, real-time clinical decision support.

Stage-adaptive audio diffusion modeling

Recent progress in diffusion-based audio generation and restoration has substantially improved performance across heterogeneous conditioning regimes, including text-conditioned audio generation and audio-conditioned super-resolution. However, training audio diffusion models remains computationally expensive, and most existing pipelines still rely on static optimization recipes that treat the relative importance of training signals as fixed throughout learning. In this work, we argue that a major source of inefficiency lies in the evolving balance between semantic acquisition and generation-oriented refinement. Early training places stronger emphasis on acquiring condition-aligned semantic structure and coarse global organization, whereas later training increasingly emphasizes temporal consistency, perceptual fidelity, and fine-detail refinement. To characterize this evolving balance, we introduce a progress-based regime variable derived from the training-time slope of an SSL-space discrepancy, which measures semantic progress during training. Based on this signal, we develop three complementary stage-aware mechanisms: decayed SSL guidance for early semantic bootstrapping, self-adaptive timestep sampling driven by the regime variable, and structure-aware regularization activated from convergent grouped organization in parameter space. We evaluate these mechanisms on text-conditioned audio generation and audio-conditioned super-resolution. Across both settings, the proposed stage-aware strategies improve convergence behavior and yield gains on the primary generation and spectral reconstruction metrics over standard static baselines. These results support the view that efficient audio diffusion training can benefit from treating external guidance, internal organization, and optimization emphasis as stage-dependent components rather than fixed ingredients.

Agentic LLM Reasoning in a Self-Driving Laboratory for Air-Sensitive Lithium Halide Spinel Conductors

Self-driving laboratories promise to accelerate materials discovery. Yet current automated solid-state synthesis platforms are limited to ambient conditions, thereby precluding their use for air-sensitive materials. Here, we present A-Lab for Glovebox Powder Solid-state Synthesis (A-Lab GPSS), a robotic platform capable of synthesizing and characterizing air-sensitive inorganic materials under strict air-free conditions. By integrating an agentic AI framework into the A-Lab GPSS platform, we structure autonomous experimental design through abductive and inductive reasoning. We deploy this platform to explore the vast compositional space of lithium halide spinel solid-state ionic conductors. Across a synthesis campaign comprising 352 samples with diverse compositions, the system explores a broad chemical space, experimentally realizing 72% of the 171 possible pairwise combinations among the 19 metals considered in this study. Over the course of the campaign, the fraction of compositions exhibiting both good ionic conductivity (> 0.05 mS/cm) and high halide spinel phase purity increases from 1.33% in the first 75 agent-proposed samples to 5.33% in the final 75. Furthermore, by inspecting the AI's reasoning processes, we reveal distinct yet complementary discovery strategies: abductive reasoning interrogates abnormal observations within already explored regions, whereas inductive reasoning expands the search into broader, previously unvisited chemical space. This work establishes a scalable platform for the autonomous discovery of complex, air-sensitive solid-state materials.

JoyAI-LLM Flash: Advancing Mid-Scale LLMs with Token Efficiency

We introduce JoyAI-LLM Flash, an efficient Mixture-of-Experts (MoE) language model designed to redefine the trade-off between strong performance and token efficiency in the sub-50B parameter regime. JoyAI-LLM Flash is pretrained on a massive corpus of 20 trillion tokens and further optimized through a rigorous post-training pipeline, including supervised fine-tuning (SFT), Direct Preference Optimization (DPO), and large-scale reinforcement learning (RL) across diverse environments. To improve token efficiency, JoyAI-LLM Flash strategically balances \emph{thinking} and \emph{non-thinking} cognitive modes and introduces FiberPO, a novel RL algorithm inspired by fibration theory that decomposes trust-region maintenance into global and local components, providing unified multi-scale stability control for LLM policy optimization. To enhance architectural sparsity, the model comprises 48B total parameters while activating only 2.7B parameters per forward pass, achieving a substantially higher sparsity ratio than contemporary industry leading models of comparable scale. To further improve inference throughput, we adopt a joint training-inference co-design that incorporates dense Multi-Token Prediction (MTP) and Quantization-Aware Training (QAT). We release the checkpoints for both JoyAI-LLM-48B-A3B Base and its post-trained variants on Hugging Face to support the open-source community.

The Evolution of Tool Use in LLM Agents: From Single-Tool Call to Multi-Tool Orchestration

Tool use enables large language models (LLMs) to access external information, invoke software systems, and act in digital environments beyond what can be solved from model parameters alone. Early research mainly studied whether a model could select and execute a correct single tool call. As agent systems evolve, however, the central problem has shifted from isolated invocation to multi-tool orchestration over long trajectories with intermediate state, execution feedback, changing environments, and practical constraints such as safety, cost, and verifiability. We comprehensively review recent progress in multi-tool LLM agents and analyzes the state of the art in this rapidly developing area. First, we unify task formulations and distinguish single-call tool use from long-horizon orchestration. Then, we organize the literature around six core dimensions: inference-time planning and execution, training and trajectory construction, safety and control, efficiency under resource constraints, capability completeness in open environments, and benchmark design and evaluation. We further summarize representative applications in software engineering, enterprise workflows, graphical user interfaces, and mobile systems. Finally, we discuss major challenges and outline future directions for building reliable, scalable, and verifiable multi-tool agents.

Fibration Policy Optimization

Large language models are increasingly trained as heterogeneous systems spanning multiple domains, expert partitions, and agentic pipelines, yet prevalent proximal objectives operate at a single scale and lack a principled mechanism for coupling token-level, trajectory-level, and higher-level hierarchical stability control. To bridge this gap, we derive the Aggregational Policy Censoring Objective (APC-Obj), the first exact unconstrained reformulation of sample-based TV-TRPO, establishing that clipping-based surrogate design and trust-region optimization are dual formulations of the same problem. Building on this foundation, we develop Fiber Bundle Gating (FBG), an algebraic framework that organizes sampled RL data as a fiber bundle and decomposes ratio gating into a base-level gate on trajectory aggregates and a fiber-level gate on per-token residuals, with provable first-order agreement with the true RL objective near on-policy. From APC-Obj and FBG we derive Fibration Policy Optimization (or simply, FiberPO), a concrete objective whose Jacobian is block-diagonal over trajectories, reduces to identity at on-policy, and provides better update direction thus improving token efficiency. The compositional nature of the framework extends beyond the trajectory-token case: fibrations compose algebraically into a Fibration Gating Hierarchy (FGH) that scales the same gating mechanism to arbitrary hierarchical depth without new primitives, as demonstrated by FiberPO-Domain, a four-level instantiation with independent trust-region budgets at the domain, prompt group, trajectory, and token levels. Together, these results connect the trust-region theory, a compositional algebraic structure, and practical multi-scale stability control into a unified framework for LLM policy optimization.

The Auton Agentic AI Framework

The field of Artificial Intelligence is undergoing a transition from Generative AI -- probabilistic generation of text and images -- to Agentic AI, in which autonomous systems execute actions within external environments on behalf of users. This transition exposes a fundamental architectural mismatch: Large Language Models (LLMs) produce stochastic, unstructured outputs, whereas the backend infrastructure they must control -- databases, APIs, cloud services -- requires deterministic, schema-conformant inputs. The present paper describes the Auton Agentic AI Framework, a principled architecture for standardizing the creation, execution, and governance of autonomous agent systems. The framework is organized around a strict separation between the Cognitive Blueprint, a declarative, language-agnostic specification of agent identity and capabilities, and the Runtime Engine, the platform-specific execution substrate that instantiates and runs the agent. This separation enables cross-language portability, formal auditability, and modular tool integration via the Model Context Protocol (MCP). The paper formalizes the agent execution model as an augmented Partially Observable Markov Decision Process (POMDP) with a latent reasoning space, introduces a hierarchical memory consolidation architecture inspired by biological episodic memory systems, defines a constraint manifold formalism for safety enforcement via policy projection rather than post-hoc filtering, presents a three-level self-evolution framework spanning in-context adaptation through reinforcement learning, and describes runtime optimizations -- including parallel graph execution, speculative inference, and dynamic context pruning -- that reduce end-to-end latency for multi-step agent workflows.

BriMA: Bridged Modality Adaptation for Multi-Modal Continual Action Quality Assessment

Action Quality Assessment (AQA) aims to score how well an action is performed and is widely used in sports analysis, rehabilitation assessment, and human skill evaluation. Multi-modal AQA has recently achieved strong progress by leveraging complementary visual and kinematic cues, yet real-world deployments often suffer from non-stationary modality imbalance, where certain modalities become missing or intermittently available due to sensor failures or annotation gaps. Existing continual AQA methods overlook this issue and assume that all modalities remain complete and stable throughout training, which restricts their practicality. To address this challenge, we introduce Bridged Modality Adaptation (BriMA), an innovative approach to multi-modal continual AQA under modality-missing conditions. BriMA consists of a memory-guided bridging imputation module that reconstructs missing modalities using both task-agnostic and task-specific representations, and a modality-aware replay mechanism that prioritizes informative samples based on modality distortion and distribution drift. Experiments on three representative multi-modal AQA datasets (RG, Fis-V, and FS1000) show that BriMA consistently improves performance under different modality-missing conditions, achieving 6--8\% higher correlation and 12--15\% lower error on average. These results demonstrate a step toward robust multi-modal AQA systems under real-world deployment constraints.

PACE: Pretrained Audio Continual Learning

Audio is a fundamental modality for analyzing speech, music, and environmental sounds. Although pretrained audio models have significantly advanced audio understanding, they remain fragile in real-world settings where data distributions shift over time. In this work, we present the first systematic benchmark for audio continual learning (CL) with pretrained models (PTMs), together with a comprehensive analysis of its unique challenges. Unlike in vision, where parameter-efficient fine-tuning (PEFT) has proven effective for CL, directly transferring such strategies to audio leads to poor performance. This stems from a fundamental property of audio backbones: they focus on low-level spectral details rather than structured semantics, causing severe upstream-downstream misalignment. Through extensive empirical study, we identify analytic classifiers with first-session adaptation (FSA) as a promising direction, but also reveal two major limitations: representation saturation in coarse-grained scenarios and representation drift in fine-grained scenarios. To address these challenges, we propose PACE, a novel method that enhances FSA via a regularized analytic classifier and enables multi-session adaptation through adaptive subspace-orthogonal PEFT for improved semantic alignment. In addition, we introduce spectrogram-based boundary-aware perturbations to mitigate representation overlap and improve stability. Experiments on six diverse audio CL benchmarks demonstrate that PACE substantially outperforms state-of-the-art baselines, marking an important step toward robust and scalable audio continual learning with PTMs.

AI Meets Brain: Memory Systems from Cognitive Neuroscience to Autonomous Agents

Memory serves as the pivotal nexus bridging past and future, providing both humans and AI systems with invaluable concepts and experience to navigate complex tasks. Recent research on autonomous agents has increasingly focused on designing efficient memory workflows by drawing on cognitive neuroscience. However, constrained by interdisciplinary barriers, existing works struggle to assimilate the essence of human memory mechanisms. To bridge this gap, we systematically synthesizes interdisciplinary knowledge of memory, connecting insights from cognitive neuroscience with LLM-driven agents. Specifically, we first elucidate the definition and function of memory along a progressive trajectory from cognitive neuroscience through LLMs to agents. We then provide a comparative analysis of memory taxonomy, storage mechanisms, and the complete management lifecycle from both biological and artificial perspectives. Subsequently, we review the mainstream benchmarks for evaluating agent memory. Additionally, we explore memory security from dual perspectives of attack and defense. Finally, we envision future research directions, with a focus on multimodal memory systems and skill acquisition.